CELLULAR AGGREGATES FOR USE IN VASCULARISATION THERAPY

    Inventors:
  1. JOSE RAMON PINEDA MARTI
  2. JON LUZURIAGA GONZALEZ
  3. FERNANDO JOSE UNDA RODRIGUEZ
  4. PASTOR ALONSO OIER
  5. JUAN MANUEL ENCINAS PEREZ
  6. GASKON IBARRETXE BILBAO
  7. IGOR IRASTORZA EPELDE
  1. Universidad del País Vasco/Euskal Herriko Unibertsitatea
    info

    Universidad del País Vasco/Euskal Herriko Unibertsitatea

    Lejona, España

  2. Achucarro Basque Center for Neuroscience
    info

    Achucarro Basque Center for Neuroscience

    Leioa, España

WO EP US
Publicación principal:

WO2020007878A1 (09-01-2020)

Otras Publicaciones:

WO2020007878A1 (09-01-2020)

US20210123025A1 (29-04-2021)

EP3817753A1 (12-05-2021)

Abstract

The present invention provides a serum-free endothelial cell differentiation culture medium comprising (a) a basal culture medium and (b) an endothelial cell differentiation combination of EGF,FGFand VEGF protein, wherein the amount of EGF is higher than the amount of FGF protein. The present invention further provides a process for the preparation of cellular aggregate suspensions comprising differentiated endothelial cells from dental stem cells using the serum-free medium, as well as the use of the resulting suspension in therapy.

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