Analisi farmakozinetiko/farmakodinamikoa antimikrobianoen erabilera hobetzeko gaixo larrietan
- Amaia Soraluce Olañeta 1
- Alicia Rodriguez Gascón 1
- Arantxazu Isla Ruiz 1
- 1 Farmazia Fakultatea, Lascaray-Ikergunea. Euskal Herriko Unibertsitatea (UPV/EHU)
ISSN: 0214-9001
Año de publicación: 2018
Número: 33
Páginas: 19-33
Tipo: Artículo
Otras publicaciones en: Ekaia: Euskal Herriko Unibertsitateko zientzi eta teknologi aldizkaria
Resumen
Nowadays, the treatment of infectious diseases has become a global health issue, due to multi-resistant antibiotic bacteria. The lack of new antibiotics enhances urgent need for current antimicrobials’ dosing regimens optimization. This could be-come an extremely challenging duty when treating some kind of patients, such as the critically ill; as due to their physiophatological situation, both pharmacokinetics and pharmacodynamics might be altered. PK/PD analysis, together with Monte Carlo Sim-ulation, might be a useful tool in order to optimize dosing regimens of antibiotic agents and, therefore, improve clinical outcome and diminish emergence of resistances.