Functional and structural characterization of peptides derived from hiv-1 gp41 membrane proximal and transmembrane domains. Implications for anti-hiv inhibitor and inmunogen development

Supervised by:
  1. Jose Luis Nieva Escandón Director

Defence university: Universidad del País Vasco - Euskal Herriko Unibertsitatea

Fecha de defensa: 11 June 2012

  1. Jesús Pérez Gil Chair
  2. Francesc Xabier Contreras Gómez Secretary
  3. Enrique Pérez Payá Committee member
  4. Jamie K. Scott Committee member
  5. Gorka Basañez Asua Committee member
  1. Bioquímica y Biología Molecular

Type: Thesis

Teseo: 116155 DIALNET


1- Relevant in vitro assays for MPER membrane activity should include:- MPER peptide redefined to bear the hydrophobic-at-interface region plus the Nterminalresidues of the TMD.- A lipid bilayer whose composition includes concentrations of cholesterol as highas those present in the viral envelope.2- Preliminary results support that in vitro assays for MPER activity, optimizedaccording to those parameters, are useful tools for new HIV-1 inhibitor and immunogendevelopment.