Functional and structural characterization of peptides derived from hiv-1 gp41 membrane proximal and transmembrane domains. Implications for anti-hiv inhibitor and inmunogen development

  1. APELLANIZ UNZALU, BEATRIZ
Supervised by:
  1. Jose Luis Nieva Escandón Director

Defence university: Universidad del País Vasco - Euskal Herriko Unibertsitatea

Fecha de defensa: 11 June 2012

Committee:
  1. Jesús Pérez Gil Chair
  2. Francesc Xabier Contreras Gómez Secretary
  3. Enrique Pérez Payá Committee member
  4. Jamie K. Scott Committee member
  5. Gorka Basañez Asua Committee member
Department:
  1. Bioquímica y Biología Molecular

Type: Thesis

Teseo: 116155 DIALNET

Abstract

1- Relevant in vitro assays for MPER membrane activity should include:- MPER peptide redefined to bear the hydrophobic-at-interface region plus the Nterminalresidues of the TMD.- A lipid bilayer whose composition includes concentrations of cholesterol as highas those present in the viral envelope.2- Preliminary results support that in vitro assays for MPER activity, optimizedaccording to those parameters, are useful tools for new HIV-1 inhibitor and immunogendevelopment.