Michael initiated organocatalytic cascade reactions

Dirigida por:
  1. José Luis Vicario Hernando Director/a
  2. María Luisa Carrillo Fernández Director/a

Universidad de defensa: Universidad del País Vasco - Euskal Herriko Unibertsitatea

Fecha de defensa: 20 de julio de 2016

  1. Esther Domínguez Pérez Presidente/a
  2. Aitor Landa Alvarez Secretario/a
  3. Maria Rita Mendes Bordalo Ventura Vocal
  4. Roser Pleixats Rovira Vocal
  5. Jose M. Sansano Gil Vocal
  1. Química Orgánica e Inorgánica

Tipo: Tesis

Teseo: 120831 DIALNET lock_openADDI editor


The methodologies based on Michael initiated cascade reactions represent avery useful synthetic strategy for the formation of complex compounds, startingfrom simple substrates and using straightforward procedures. In this dissertation,the organocatalysis has been used as the main tool to promote the reactions and toachieve an efficient enantiocontrol, employing chiral amines as stereoinductorselements, under iminium ion activation, towards the synthesis of enantioenrichedchiral proline derivatives, bicyclic and tricyclic compounds in good yields.Moreover, as part of a short stay in the Prof. Christmann group at Free Universityof Berlin, the total synthesis of the natural product (+)-Greek tobacco lactone hasbeen completed.