Michael initiated organocatalytic cascade reactions

Supervised by:
  1. José Luis Vicario Hernando Director
  2. María Luisa Carrillo Fernández Director

Defence university: Universidad del País Vasco - Euskal Herriko Unibertsitatea

Fecha de defensa: 20 July 2016

  1. Esther Domínguez Pérez Chair
  2. Aitor Landa Alvarez Secretary
  3. Maria Rita Mendes Bordalo Ventura Committee member
  4. Roser Pleixats Rovira Committee member
  5. Jose M. Sansano Gil Committee member
  1. Química Orgánica e Inorgánica

Type: Thesis

Teseo: 120831 DIALNET lock_openADDI editor


The methodologies based on Michael initiated cascade reactions represent avery useful synthetic strategy for the formation of complex compounds, startingfrom simple substrates and using straightforward procedures. In this dissertation,the organocatalysis has been used as the main tool to promote the reactions and toachieve an efficient enantiocontrol, employing chiral amines as stereoinductorselements, under iminium ion activation, towards the synthesis of enantioenrichedchiral proline derivatives, bicyclic and tricyclic compounds in good yields.Moreover, as part of a short stay in the Prof. Christmann group at Free Universityof Berlin, the total synthesis of the natural product (+)-Greek tobacco lactone hasbeen completed.