JOSE ANGEL
FERNANDEZ HIGUERO
Researcher in the period 2016-2020
Publications (19) JOSE ANGEL FERNANDEZ HIGUERO publications
2024
2023
-
The self-association equilibrium of DNAJA2 regulates its interaction with unfolded substrate proteins and with Hsc70
Nature communications, Vol. 14, Núm. 1, pp. 5436
2021
-
All-or-none amyloid disassembly via chaperone-triggered fibril unzipping favors clearance of α-synuclein toxic species
Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, Núm. 36
-
MLb-LDLr: A Machine Learning Model for Predicting the Pathogenicity of LDLr Missense Variants
JACC: Basic to Translational Science, Vol. 6, Núm. 11, pp. 815-827
-
Truncation‐driven lateral association of α‐synuclein hinders amyloid clearance by the Hsp70‐based disaggregase
International Journal of Molecular Sciences, Vol. 22, Núm. 23
2020
-
Extraction and Refolding Determinants of Chaperone-Driven Aggregated Protein Reactivation
Journal of Molecular Biology, Vol. 432, Núm. 10, pp. 3239-3250
2019
-
Regulation of Human Hsc70 ATPase and Chaperone Activities by Apg2: Role of the Acidic Subdomain
Journal of Molecular Biology, Vol. 431, Núm. 2, pp. 444-461
-
Structural and functional insights on the roles of molecular chaperones in the mistargeting and aggregation phenotypes associated with primary hyperoxaluria type I
Advances in Protein Chemistry and Structural Biology (Academic Press Inc.), pp. 119-152
2018
-
Activation of the DnaK-ClpB Complex is Regulated by the Properties of the Bound Substrate
Scientific Reports, Vol. 8, Núm. 1
2016
-
Crowding Modulates the Conformation, Affinity, and Activity of the Components of the Bacterial Disaggregase Machinery
Journal of Molecular Biology, Vol. 428, Núm. 11, pp. 2474-2487
-
Structural changes induced by acidic pH in human apolipoprotein B-100
Scientific Reports, Vol. 6
2015
-
Chaperone-assisted protein aggregate reactivation: Different solutions for the same problem
Archives of Biochemistry and Biophysics, Vol. 580, pp. 121-134
-
ClpB dynamics is driven by its ATPase cycle and regulated by the DnaK system and substrate proteins
Biochemical Journal, Vol. 466, Núm. 3, pp. 561-570
-
Structural analysis of APOB variants, p.(Arg3527Gln), p.(Arg1164Thr) and p.(Gln4494del), causing Familial Hypercholesterolaemia provides novel insights into variant pathogenicity
Scientific Reports, Vol. 5
2014
-
Human LDL structural diversity studied by IR spectroscopy
PLoS ONE, Vol. 9, Núm. 3
2011
-
Allosteric communication between the nucleotide binding domains of caseinolytic peptidase B
Journal of Biological Chemistry, Vol. 286, Núm. 29, pp. 25547-25555
-
Low-density lipoprotein density determination by electric conductivity
Analytical Biochemistry, Vol. 417, Núm. 2, pp. 283-285
2010
-
Nucleotide utilization requirements that render ClpB active as a chaperone
FEBS Letters, Vol. 584, Núm. 5, pp. 929-934
2008
-
Protein stability studied by infrared spectroscopy
Biotechnology and Biotechnological Equipment, Vol. 22, Núm. 1, pp. 625-628