Chapter 7. Lipid–Protein Interactions in G Protein Signal Transduction

  1. López, David J.
  2. Álvarez, Rafael
  3. Escribá, Pablo V.
Libro:
Drug Discovery

ISSN: 2041-3211

Año de publicación: 2011

Páginas: 153-178

Tipo: Capítulo de Libro

DOI: 10.1039/9781849733441-00153 GOOGLE SCHOLAR lock_openAcceso abierto editor

Resumen

G protein-coupled receptors (GPCRs) represent the major family of membrane proteins and regulate a wide variety of pivotal cellular processes. The activity of GPCRs and their transducers, G proteins, is influenced by lipid modifications which occur co- or post-translationally. Moreover, as membrane proteins, they are modulated by the lipid environment in which they receive and propagate signals. This chapter reviews the interactions between lipids (both single lipid molecules and membrane lipid structures) and proteins involved in the propagation of signals received by GPCRs. The modulation of these signal cascades through interventions on the lipid bilayer can be used to treat several pathologies (membrane–lipid therapy).