A direct route to Erythrinanes via α-amidoalkylation, conjugate addition and ring-closing metathesis reactions

  1. Osante, Inaki
  2. Sotomayor, Nuria
  3. Lete, Esther
Revista:
Letters in Organic Chemistry

ISSN: 1570-1786

Año de publicación: 2004

Volumen: 1

Número: 4

Páginas: 323-325

Tipo: Artículo

DOI: 10.2174/1570178043400712 GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Letters in Organic Chemistry

Resumen

A direct route to erythrinanes has been completed by a sequence that involves diastereoselective conjugate addition on a α,β-unsaturated lactam, followed by a ring-closing metathesis reaction to construct ring A. The synthesis of the key intermediates C-10b functionalized dihydropyrroloisoquinolines is achieved via Parham cyclisation and α-amidoalkylation reactions.