Sexu-desberdintasunak Parkinson gaixotasunean

  1. Zubelzu, Maider
  2. Leivar, Andrea
  3. Morera-Herreras, Teresa 1
  4. Murueta-Goyena, Ane
  1. 1 Farmakologia Saila. Medikuntza eta Erizaintza Fakultatea. Euskal Herriko Unibertsitatea (UPV/EHU)
Journal:
Ekaia: Euskal Herriko Unibertsitateko zientzi eta teknologi aldizkaria

ISSN: 0214-9001

Year of publication: 2023

Issue: 44

Pages: 41-62

Type: Article

DOI: 10.1387/EKAIA.23974 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Ekaia: Euskal Herriko Unibertsitateko zientzi eta teknologi aldizkaria

Abstract

Increasing evidence indicates that biological sex is an important factor in the development and phe-notypic expression of Parkinson’s disease. The prevalence of Parkinson’s disease affects men twice more often than women. However, women experience a more rapid progression of the disease. In addition, it is increasingly ac-knowledged that the frequency and/or severity of motor and non-motor symptoms are different in female and male patients with Parkinson’s disease. It is also considered that their response to pharmacological and surgical treat-ments differs significantly. Although the precise underlying mechanisms supporting sex differences are still to be elucidated, the pathophysiological underpinnings are presumably different in women and men with Parkinson’s dis-ease. This review aims to gather the current evidence regarding sex differences in clinical features, risk factors, pathophysiological mechanisms and response to treatments (pharmacological and surgical). Clarifying how the dis-ease affects each sex can improve patient care by tailoring the therapeutic management of men and women and by developing innovative programmes to respond to unmet needs.