Conceptos generales sobre el metabolismo del hierro

  1. Juan José Alonso Alonso 1
  2. A. Cánovas Fernández 1
  3. Ramiro de la Prieta 1
  4. T. Pereira 1
  5. C. Ruiz 1
  6. C. Aguirre 1
  1. 1 Hospital de Cruces
    info

    Hospital de Cruces

    Barakaldo, España

    ROR https://ror.org/03nzegx43

Journal:
Gaceta médica de Bilbao: Revista oficial de la Academia de Ciencias Médicas de Bilbao. Información para profesionales sanitarios

ISSN: 0304-4858,  2173-2302

Year of publication: 2002

Volume: 99

Issue: 2

Pages: 33-37

Type: Article

DOI: 10.1016/S0304-4858(02)74392-8 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Gaceta médica de Bilbao: Revista oficial de la Academia de Ciencias Médicas de Bilbao. Información para profesionales sanitarios

Abstract

Iron metabolism regulation as for the limitation of intestinal absortion and distribution to different cells and cellular compartments remains a mistery to us. However recent researchs on this issue provide both clarifying facts and new riddles to solve. New proteins taking part in different stages of iron metabolism have come into play: integrin, mobilferrin and DMT-1 in intestinal absortion; ferroportin and haephestin related to iron release to transferrin from the enterocyte; transferrin receptor for iron uptake by cells, and iron regulatory proteins (IRP) and iron responsive elements (IRE) in management of intracellular level of active iron. Despite its momentary limited repercusion in ordinary clinical labour these findings can never be ignored as far as iron related pathology is concerned.

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