Lipoproteína(a), variables antropométricas, parámetros lipídicos y trombogénicos en la infancia
- Jesús Pablo Sáez de Lafuente 2
- Yolanda Sáez 3
- Marta Vacas 3
- Manuel Lafita 3
- Idoia Narváez 3
- Mónica Santos 3
- José Domingo Sagastagoitia 1
- Enrique Molinero 1
- José Antonio Iriarte 3
- 1 Servicio de Cardiología. Hospital de Basurto. Bilbao. Vizcaya
- 2 Departamento de Enfermería. Universidad del País Vasco. Bilbao. Vizcaya. España
- 3 Trombosis y Hemostasia. Fundación para la Investigación y Docencia de las Enfermedades Cardiovasculares (FIDEC). Bilbao. Vizcaya
ISSN: 0214-9168, 1578-1879
Año de publicación: 2006
Volumen: 18
Número: 3
Páginas: 82-88
Tipo: Artículo
Otras publicaciones en: Clínica e investigación en arteriosclerosis
Resumen
Introduction Lipoprotein(a) is a risk factor for cardiovascular disease. The purpose of this study was to determine the distribution of Lp(a) levels in children and to evaluate its relationship with anthropometric measures, and lipid and thrombogenic factors. Material and methods Serum levels of Lp(a), total cholesterol, triglycerides, high-density lipoprotein (cHDL)-cholesterol, low-density lipoprotein (cLDL)-cholesterol, fibrinogen, D-dimer and plasminogen activator inhibitor (PAI-1), as well as weight and height, were measured in 98 apparently healthy boys and girls aged 6-7 years old. Results Serum Lp(a) levels ranged from 0.17 to 120 mg/dl (median: 5.56 mg/dl; interquartile range: 2.37-13.46). Levels higher than 30 mg/dl were found in 9.1% of the children. Lp(a) concentrations were higher in the group of children with a family history of cardiovascular disease, although this difference was not statistically significant. A positive and significant correlation was found between Lp(a) levels cLDL and a negative and significant correlation was found with weight. No correlation was observed between Lp(a) levels and thrombogenic factors. Conclusions In view of the additive effect of cardiovascular risk factors and the data obtained in this study, we believe that Lp(a) determination should be considered in children with high LDL-c levels or a family history of cardiovascular disease.