Angina bullosa hemorrhagica an enigmatic oral disease

  1. Alberdi-Navarro, Javier 1
  2. Gainza-Cirauqui, ML 2
  3. Prieto-Elías, M 1
  4. Aguirre-Urizar ,JM. 1
  1. 1 Universidad del País Vasco/Euskal Herriko Unibertsitatea

    Universidad del País Vasco/Euskal Herriko Unibertsitatea

    Lejona, España


  2. 2 Department of Dental Surgery, Faculty of Dental Surgery, University of Malta, 2080 Msida, Malta
World Journal of Stomatology

ISSN: 2218-6263

Year of publication: 2015

Volume: 4

Issue: 1

Pages: 1-7

Type: Article

DOI: 10.5321/WJS.V4.I1.1 GOOGLE SCHOLAR lock_openOpen access editor

More publications in: World Journal of Stomatology


Angina bullosa hemorrhagica (ABH) is an enigmatic oral disorder described for the first time by Badham in 1967 to define blisters with a hematic content in the oral cavity and oropharynx unrelated to any hematological, dermatological or systemic disease. The ABH is an uncommon disease of the oral cavity distinctively affecting adults, with the highest incidence over the 5th decade of life. This process is considered nowadays to have a multifactorial etiopathogenesis, where mild oral traumatisms can trigger the blisters in susceptible individuals. Certain association on the onset of the lesion with the chronic use of inhaled steroids and, more controversially, with triggering systemic disorders, such as, diabetes or hypertension has been described. Characteristically, the ABH blisters are acute and are located on the lining mucosa, more frequently on the soft palate. Usually, the lesions are solitary and rupture easily, resulting in a superficial ulceration that heals quickly without scarring. The histopathological analysis shows a subepithelial blister containing blood and direct immunofluorescence on the epithelium is negative. The differential diagnosis should consider all oral vesiculo-bullous disorders with hematic content, including mucocutaneos, hematological or cystic pathology. The diagnosis of ABH is clearly clinical, although the biopsy might be helpful on atypical or abnormally recurrent cases. The general prognosis of ABH is good and the treatment is symptomatic.

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