Cyclobutane-containing peptides and ureassynthesis, folding, self-assembling and some biological properties

Resumen

Peptides and relative compounds, have been widely used and studied during the past decades. In the present thesis, an enantioselective synthesis and structural study of a variety of cyclobutane-containing beta-peptides and ureas is exposed. By means of experimental and theoretical techniques, their adoption of different folding structures due to the presence of self-assembling properties is described. These properties, in some cases, allowed the preparation of stable gels in organic solvents, which obtaintion was fully studied. In addition, the use of solid-phase peptide synthesis strategy was assaied in order to prepare hybrid cyclobutane-proline hexapeptides. Those, were studied as possible cell-penetrating agents.