New approaches to cancer treatmentmicrowire-based magnetic hyperthermia

  1. O. Mitxelena-Iribarren 1
  2. I. Martínez de Apellániz 1
  3. S. Lizarbe-Sancha 2
  4. S. Arana 2
  5. Zhukova 3
  6. Zhukov, Arkady
  7. M. Mujika 5
  1. 1 Universidad de Navarra
    info

    Universidad de Navarra

    Pamplona, España

    ROR https://ror.org/02rxc7m23

  2. 2 Ceit, Donostia-San Sebastián, Spain
  3. 3 UPV/EHU, 20018, Donostia-San Sebastián, Spain
  4. 4 IKERBASQUE, Basque Foundation for Science, Bilbao, Spain
  5. 5 Ceit, Manuel Lardizábal 15, 20018 Donostia-San Sebastián, Spain
Erakutsi afiliazioak +
Liburua:
Libro de Actas del XXXVI Congreso Anual de la Sociedad Española de Ingeniería Biomédica

Argitaletxea: Jesús Salido Tercero ; Ma del Milagro Fernández Carrobles ; Óscar Déniz Suárez ; Ma Gloria Bueno García

ISBN: 978-84-09-06253-9

Argitalpen urtea: 2018

Orrialdeak: 245-248

Biltzarra: Congreso Anual de la Sociedad Española de Ingeniería Biomédica CASEIB (36. 2018. Ciudad Real)

Mota: Biltzar ekarpena

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Laburpena

Although significantly improved, current treatments against cancer still present remarkable drawbacks related mainly to side effects. The effectiveness of surgery, radiotherapy, chemotherapy and their combinations, besides being limited in some cases, does not always make up for the undesired invasive nature of these treatments. Therefore, the need for new approaches to overcome these difficulties is apparent. Targeted therapies appear at this scene as great potential alternatives for oncology. Among them, nanoparticle based magnetic hyperthermia stands out as a valuable technique. Clinical validation steps have highlighted some major hindrances due to clearance and toxicity, though. In this work, a novel hyperthermia approach is presented, where the targeted cell death was achieved by means of glass-coated magnetic microwires. These microvehicles were embedded into an elastomer-based microfluidic chambers, where the target osteosarcoma cells were cultured. For treatment periods below an hour the proposed method was demonstrated to be highly effective against cancer cells killing 85% of the treated population.

Datuen iturria: Dialnet