Sare metal-organikoetan oinarritutako farmakoen liberazio sistemakbiomolekulak atxikitzeko funtzionalizazio-estrategiak
- 1 Basque Center for Materials, Applications and Nanostructures (BCMaterials) eta Euskal Herriko Unibertsitatea (UPV/EHU).
ISSN: 0214-9001
Argitalpen urtea: 2022
Zenbakia: 42
Orrialdeak: 227-239
Mota: Artikulua
Beste argitalpen batzuk: Ekaia: Euskal Herriko Unibertsitateko zientzi eta teknologi aldizkaria
Laburpena
Drug delivery systems (DDSs) based on metal-organic frameworks (MOFs) overcome the limits shown by conventionally used drug delivery systems. Due to their hybrid inorganic-organic nature, MOFs are able to combine the advantages shown by inorganic and organic based conventional DDSs, while minimising their drawbacks. In this work, after explaining the general characteristics that DDS systems must fullfil, the key properties of MOFs for their use as DDSs are discussed. More specifically, the five most used functionalization strategies to achieve a controled incorporation and/or release of biomolecules within MOF structures will be explained.