Balizko molekula fotoaktibo multifuntzionala biomedikuntzarako
- Avellanal-Zaballa, Edurne 1
- Oliden-Sánchez, Ainhoa 1
- Sola-Llano, Rebeca 1
- Gartzia-Rivero, Leire 1
- Bañuelos, Jorge 1
- 1 Euskal Herriko Unibertsitatea (UPV-EHU)
ISSN: 0214-9001
Año de publicación: 2021
Número: 41
Páginas: 207-224
Tipo: Artículo
Otras publicaciones en: Ekaia: Euskal Herriko Unibertsitateko zientzi eta teknologi aldizkaria
Resumen
Light-emitting organic molecules are appealing for diagnosis in biomedicine. Fluorescence is a valuable tool to visualize ongoing biochemical processes and biomolecules in the human body with great sensibility and easily. Thus, photoactive dyes are applied as fluorescent tags, probes and sensors to monitor biochemical processes, organelles and biomolecules, respectively, by means of fluorescence microscopy. Moreover, no-fluorescent dyes but able to generate singlet oxygen can be applied as photosensitizers for photodynamic therapy in the treatment of cancer. In each of the aforementioned areas dealing with biophotonics, different chromophores are required owing to the opposite photophysical signatures demanded. Herein, we propose BODIPY called chromophore as a molecular scaffold for diagnosis and therapy. The chemical versatility and tunable photophysics of this chromophoric core enables tailoring by the appropriate substitution pattern. Therefore, our aim is to highlight the importance of molecular design to develop fluorophores as well as photosensitizers based solely in BODIPY.