Listu-guruinaren enbriogenesia eta seinalizazio-bideak.
ISSN: 0214-9001
Year of publication: 2019
Issue: 36
Pages: 163-174
Type: Article
More publications in: Ekaia: Euskal Herriko Unibertsitateko zientzi eta teknologi aldizkaria
Abstract
Mammalian salivary gland is an epithelial structure that is highly branched during development and is designed to produce and secrete saliva in the body. There are three main types of salivary glands; however, the most commonly studied is submandibular salivary gland. This review describes the different stages of the mouse embryo salivary gland development. At the same time, it summarizes the basic signaling pathways and mechanisms that guide this development process; FGF, Shh, Notch, Wnt, Eda, ECMs and the nervous system. Understanding the mechanisms that operate during development is essential for the design of effective therapies for affected gland and regeneration.