Experiencia con rosiglitazona como tratamiento rediferenciador en un caso de carcinoma papilar de tiroides con metástasis pulmonares y ausencia de captación de radioyodo
- Maitane Elola Zeberio
- Alfredo Yoldi Arrieta
- José Ignacio Emparanza
- Tomás Matteucci Armesto
- Ismene Bilbao Garay
- Miguel María Goena Iglesias
ISSN: 0212-6982
Year of publication: 2011
Volume: 30
Issue: 4
Pages: 241-243
Type: Article
More publications in: Revista española de medicina nuclear
Sustainable development goals
Abstract
Abstract Treatment with radioiodine (RDI) has been shown to be an effective option in patients with differentiated thyroid cancer with recurrent or metastatic disease. However, in spite of having elevated levels of thyroglobulin in blood, in some of these patients, the whole body scan does not detect radioiodine uptake due to loss of differentiation of the neoplastic cells, thus leading to loss of efficacy of the treatment. That is why drugs with potential differentiating properties, like rosiglitazone or retinoids, are being studied. The aim of these drugs is to improve RDI uptake by the tumor cells. In this work, we have described the case of a patient in whom uptake of RDI by the pulmonary metastases, with subsequent decrease of their size, was achieved after treatment with rosiglitazone (8mg/day for 2 months) as redifferentation therapy.