Factores de riesgo de la coriorretinopatía serosa centralcasos y controles

Abstract

Purpose: To identify systemic factors associated with the development of central serous chorioretinopathy (CSCR). Methods: Case-control prospective study: 27 cases and 36 controls. Demographic features, endogenous cortisol levels in urine (24 hour free urine cortisol) and Helicobacter pylori infection (assessed by the 13c-urea breath test), were determined in 27 patients with acute central serous chorioretinopathy (CSCR) and compared with a control group. Results: This study identified stress (p=0.012), and alcohol abuse (p=0,053) associated with CSCR. There is a potential association between CSCR and systemic corticosteroid use (p=0,29), recent drug use (cocaine, speed) (p=0.28) and Helicobacter pylori infection p=27 [Odds ratio=1.88 (0.52-6.76)]. This study identified no association of CSCR with tobacco smoking (p=0.99) and allergic respiratory disease (p=0,99). The mean values of 24 four hour urine cortisol (57.66 µg/24 h v 65.8 µg/24 h) revealed higher values in the control group (p=0.35). Conclusions: These findings reinforce that stress play a role in the development of CSCR. This study also identified alcohol abuse as a risk factor of CSCR. This study find no significant association between corticosteroid use, recent drug use (cocaine, speed) and Helicobacter pylori infection. However, bigger sample size prospective studies are needed to evaluate the significance of these potential associations. This study identifies no association of CSCR with tobacco smoking, allergic respiratory disease and endogenous cortisol levels in urine, in contrast with previous studies.