Distribución mundial de la diversidad genética asociada a la estatura humana adulta

  1. Torreiro, A. 1
  2. Izagirre, N. 1
  3. Alonso, S. 1
  1. 1 Universidad Politécnica de Valencia
    info

    Universidad Politécnica de Valencia

    Valencia, España

    ROR https://ror.org/01460j859

Journal:
Revista española de antropología física

ISSN: 2253-9921

Year of publication: 2020

Issue: 41

Pages: 43-59

Type: Article

More publications in: Revista española de antropología física

Abstract

Genome-wide association studies (GWAS) are widely used to investigate the genetic basis of many complex traits. One of the most studied human traits is height, a phenotype of great interest as a proxy for human growth. Human height is influenced by both the genome and the environment, and it is difficult to estimate the contribution of each of these factors to the total variation of adult height. In this work, after analyzing a set of 823 SNPs related to human height by means of Principal Component Analysis (PCA), we observed that the global geographical distribution of these variants showed a great heterogeneity, reflecting a remarkable variability within and among continents. In addition, we found a positive correlation between the genetic heritage of Europeans, in particular with that of the populations of Northern and Central Europe, and a higher expected height.