Transcriptome regulation network in multiple sclerosisrole of circular rnas

  1. Iparraguirre Gil, Leire
Supervised by:
  1. David Otaegui Bichot Director
  2. Maider Muñoz Culla Director
  3. Adolfo López de Munain Arregui Director

Defence university: Universidad del País Vasco - Euskal Herriko Unibertsitatea

Fecha de defensa: 09 February 2021

  1. Sergio E. Baranzini Chair
  2. Ainhoa Iglesias Ara Secretary
  3. Lasse Sommer Kristensen Committee member
  1. Procesos Psicológicos Básicos y Desarrollo

Type: Thesis

Teseo: 153716 DIALNET lock_openADDI editor


Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system, that leads to neurological disability. The disease course and clinical phenotype are highly variable and therefore, biomarkers that can aid in the clinical practice are needed. Previous studies have shown a dysregulation in the coding and non-coding RNAs and proposed some as biomarkers. However, still none of them have reached the clinical practice. Recently, circular RNAs (circRNAs) have emerged as new players in the transcriptome that hold a great potential as biomarkers thanks to the features endowed by their circularity. In this thesis, we have performed different approaches to characterise the circRNA expression in leukocytes, peripheral blood mononuclear cells and extracellular vesicles from MS patients. Results have revealed hundreds of circRNAs whose expression is changed in the disease, and we have proposed eleven of them as potential minimally-invasive biomarkers. Finally, our functional experiments indicate that circRNAs may act as regulators of the immune response. This thesis opens a new research line in MS for future investigations to further evaluate the biomarker potential and the function of circRNAs in MS.