Clinicopathological and prognostic characterization of oral lichenoid disease and its main subtypesa series of 384 cases

  1. José Manuel Aguirre Urizar 1
  2. Javier Alberdi Navarro 1
  3. Irene Lafuente-Ibáñez de Mendoza 1
  4. Xabier Marichalar Mendia 1
  5. Begoña Martínez Revilla 1
  6. María del Carmen Parra Pérez 1
  7. A. de Juan Galíndez 1
  8. María Ángeles Echebarria Goicouria 1
  1. 1 Oral Medicine and Oral and Maxillofacial Pathology Units. Dental Clinic Service. Master of Oral Pathology. Department of Stomatology II. University of the Basque Country (UPV/EHU). Leioa, Spain
Revista:
Medicina oral, patología oral y cirugía bucal. Ed. inglesa

ISSN: 1698-6946

Año de publicación: 2020

Volumen: 25

Número: 4

Páginas: 2

Tipo: Artículo

DOI: 10.4317/MEDORAL.23576 DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Medicina oral, patología oral y cirugía bucal. Ed. inglesa

Resumen

To clinicopathologically characterize the diagnosis of oral lichenoid disease (OLD) and its main subtypes: oral lichen planus (OLP) and oral lichenoid lesion (OLL), in order to correctly asses their prognosis. Ambispective cohort study of 384 patients with diagnosis of OLD, based on pre-established clinical and histopathological criteria. We have analysed 272 (70.8%) women and 112 (29.2%), whose mean age was 57.1+/-11.8 years (range 21-90); minimum follow-up time was 36 months. A specific protocol was designed for this study, where we gathered the data of each patient, including malignant transformation. OLP was diagnosed in 229 cases (77.9%) and OLL in 85 (22.1%). Tobacco consumption was found in 20.3% of the patients and alcohol intake in 41.1%. Liver pathology was present in 10.7% of the cases, thyroid pathology in 11.5%, arterial hypertension in 15.6%, diabetes mellitus in 7.6%, psycho-emotional disorders in 33.3%, skin involvement in 12% and genital involvement in 4.9%. Ten patients (2.6%) developed an oral squamous cell carcinoma, 5 (1.7%) with OLP and 5 (5.9%) with OLL. OLD is a potentially malignant disorder of the oral mucosa which has to be correctly diagnosed as either OLP or OLL, since the risk of malignancy of these subtypes is significantly different.

Referencias bibliográficas

  • Al-Hashimi, I,Schifter, M,Lockhart, PB,Wray, D,Brennan, M,Migliorati, CA. (2007). Oral lichen planus and oral lichenoid lesions: diagnostic and therapeutic considerations. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 103. 1-12
  • van der Waal, I. (2009). Oral lichen planus and oral lichenoid lesions; a critical appraisal with emphasis on the diagnostic aspects. Med Oral Patol Oral Cir Bucal. 14. 310
  • Carrozzo, M,Porter, S,Mercadante, V,Fedele, S. (2019). Oral lichen planus: A disease or a spectrum of tissue reactions? Types, causes, diagnostic algorhythms, prognosis, management strategies. Periodontol 2000. 80. 105
  • González-Moles, MA,Scully, C,Gil-Montoya, JA. (2008). Oral lichen planus: controversies surrounding malignant transformation. Oral Dis. 14. 229
  • Fitzpatrick, SG,Hirsch, SA,Gordon, SC. (2014). The malignant transformation of oral lichen planus and oral lichenoid lesions: a systematic review. J Am Dent Assoc. 145. 45-56
  • González-Moles, MA,Gil-Montoya, JA,Ruiz-Avila, I,Bravo, M. (2017). Is oral cancer incidence among patients with oral lichen planus/oral lichenoid lesions underestimated?. J Oral Pathol Med. 46. 148
  • González-Moles, MA,Ruiz-Ávila, I,González-Ruiz, L,Ayén, Á,Gil-Montoya, JA,Ramos-Garcia, P. (2019). Malignant transformation risk of oral lichen planus: A systematic review and comprehensive meta-analysis. Oral Oncol. 96. 121
  • Aguirre Urizar, JM. (2008). Letter to the editor: Oral lichenoid disease. A new classification proposal. Med Oral Patol Oral Cir Bucal. 13. 224
  • Kramer, IR,Lucas, RB,Pindborg, JJ,Sobin, LH. (1978). Definition of leukoplakia and related lesions: an aid to studies on oral precancer. Oral Surg Oral Mes Oral Pathol. 46. 518
  • van der Meij, EH,van der Waal, I. (2003). Lack of clinicopathologic correlation in the diagnosis of oral lichen planus based on the presently available diagnostic criteria and suggestions for modifications. J Oral Pathol Med. 32. 507
  • van der Meij, EH,Schepman, KP,van der Waal, I. (2003). The possible premalignant character of oral lichen planus and oral lichenoid lesions: a prospective study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 96. 164
  • van der Meij, EH,Mast, H,van der Waal, I. (2007). The possible premalignant character of oral lichen planus and oral lichenoid lesions: a prospective five-year follow-up study of 192 patients. Oral Oncol. 43. 742
  • Cortés-Ramírez, DA,Gainza-Cirauqui, ML,Echebarria-Goicouria, MA,Aguirre-Urizar, JM. (2009). Oral lichenoid disease as a premalignant condition: the controversies and the unknown. Med Oral Patol Oral Cir Bucal. 14. 118
  • Alberdi-Navarro, J,Marichalar-Mendia, X,Lartitegui-Sebastián, MJ,Gainza-Cirauqui, ML,Echebarria-Goikouria, MA,Aguirre-Urizar, JM. (2017). Histopathological characterization of the oral lichenoid disease subtypes and the relation with the clinical data. Med Oral Patol Oral Cir Bucal. 22. 307
  • Cheng, YS,Gould, A,Kurago, Z,Fantasia, J,Muller, S. (2016). Diagnosis of oral lichen planus: a position paper of the American Academy of Oral and Maxillofacial Pathology. Oral Surg Oral Med Oral Pathol Oral Radiol. 122. 332
  • Bermejo-Fenoll, A,Sánchez-Siles, M,López-Jornet, P,Camacho-Alonso, F,Salazar-Sánchez, N. (2010). A retrospective clinicopathological study of 550 patients with oral lichen planus in south-eastern Spain. J Oral Pathol Med. 39. 491
  • Aghbari, SMH,Abushouk, AI,Attia, A,Elmaraezy, A,Menshawy, A,Ahmed, MS. (2017). Malignant transformation of oral lichen planus and oral lichenoid lesions: A meta-analysis of 20095 patient data. Oral Oncol. 68. 92-102
  • Warnakulasuriya, S. (2018). Clinical features and presentation of oral potentially malignant disorders. Oral Surg Oral Med Oral Pathol Oral Radiol. 125. 582
  • Giuliani, M,Troiano, G,Cordaro, M,Corsalini, M,Gioco, G,Lo Muzio, L. (2019). Rate of malignant transformation of oral lichen planus: A systematic review. Oral Dis. 25. 693-709
  • Rock, LD,Laronde, DM,Lin, I,Rosin, MP,Chan, B,Shariati, B. (2018). Dysplasia should not be ignored in lichenoid mucositis. J Dent Res. 97. 767
  • Warnakulasuriya, S,Tilakaratne, WM,Ranganathan, K,Kuriakose, MA. (2018). Report of a consensus meeting of a group of oral and general pathologists in India on grading of oral epithelial dysplasia. Oral Oncol. 81. 109
  • Trofor, AC,Papadakis, S,Lotrean, LM,Radu-Loghin, C,Eremia, M,Mihaltan, F. (2019). Knowledge of the health risks of smoking and impact of cigarette warning labels among tobacco users in six European countries: Findings from the EUREST-PLUS ITC Europe Surveys. Tob Induc Dis. 16. 10
  • del Olmo, JA,Pascual, I,Bagán, JV,Serra, MA,Escudero, A,Rodríguez, F. (2000). Prevalence of hepatitis C virus in patients with lichen planus of the oral cavity and chronic liver disease. Eur J Oral Sci. 108. 378
  • Robledo-Sierra, J,Landin-Wilhelmsen, K,Nyström, HF,Mattsson, U,Jontell, M. (2015). Clinical characteristics of patients with concomitant oral lichen planus and thyroid disease. Oral Surg Oral Med Oral Pathol Oral Radiol. 120. 602
  • Menéndez, E,Delgado, E,Fernández-Vega, F,Prieto, MA,Bordiú, E,Calle, A. (2016). Prevalencia, diagnóstico, tratamiento y control de la hipertensión arterial en España. Resultados del estudio Di@bet.es. Rev Esp Cardiol. 69. 572
  • Rojo-Moreno, JL,Bagán, JV,Rojo-Moreno, J,Donat, JS,Milián, MA,Jiménez, Y. (1998). Psychologic factors and oral lichen planus. A psychometric evaluation of 100 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 86. 687
  • García-Pola, MJ,Llorente-Pendás, S,González-Garcia, M,García-Martín, JM. (2016). The development of proliferative verrucous leukoplakia in oral lichen planus. A preliminary study. Med Oral Patol Oral Cir Bucal. 21. 328
  • Camacho-Alonso, F,López-Jornet, P,Bermejo-Fenoll, A. (2007). Gingival involvement of oral lichen planus. J Periodontol. 78. 640
  • Izarzugaza, MI,Esparza, H,Aguirre, JM. (2001). Epidemiological aspects of oral and pharyngeal cancers in the Basque Country. J Oral Pathol Med. 30. 521
  • Mignogna, MD,Fedele, S,Lo Russo, L,Mignogna, C,de Rosa, G,Porter, SR. (2007). Field cancerization in oral lichen planus. Eur J Surg Oncol. 33. 383
Fuente de los datos: Dialnet