Pharmacokinetic-pharmacodynamic modeling of the antinociceptive effects of main active metabolites of tramadol, (+)-O-desmethyltramadol and (-)-O- desmethyltramadol, in rats

1. Valle, M.
2. Garrido, M.J.
3. Pavón, J.M.
4. Calvo, R.
5. Trocóniz, I.F.