Alpha-1-acid glycoprotein directly affects the pharmacokinetics and the analgesic effect of methadone in the rat beyond protein binding

  1. Rodriguez, M.
  2. Ortega, I.
  3. Soengas, I.
  4. Leal, N.
  5. Suarez, E.
  6. Calvo, R.
  7. Lukas, J.C.
Journal:
Journal of Pharmaceutical Sciences

ISSN: 0022-3549

Year of publication: 2004

Volume: 93

Issue: 11

Pages: 2836-2850

Type: Article

DOI: 10.1002/JPS.20171 GOOGLE SCHOLAR