Peri-implant peripheral giant cell lesionsreport of 13 new cases and comparative histological and immunohistochemical analysis with peripheral and central giant cell lesions
- Thayná-Melo-de Lima Morais 1
- Ciro Dantas Soares 1
- José Manuel Aguirre Urizar 2
- Javier Alberdi Navarro 2
- Oslei Paes de Almeida 3
- Fábio-Ramôa Pires 4
- 1 MSc, Oral Pathology, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Brazil
- 2 PhD, Oral Pathology and Medicine, Department of Stomatology II, University of the Basque Country (UPV/EHU), Leioa (Bizkaia), Spain
- 3 PhD, Oral Pathology, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Brazil
- 4 PhD, Oral Pathology, School of Dentistry, State University of Rio de Janeiro, Brazil
ISSN: 1698-6946
Argitalpen urtea: 2019
Alea: 24
Zenbakia: 6
Orrialdeak: 2
Mota: Artikulua
Beste argitalpen batzuk: Medicina oral, patología oral y cirugía bucal. Ed. inglesa
Laburpena
Few cases or peri-implant peripheral giant cell lesions (PGCL) have been reported in the literature. The aim of this study was to report 13 new cases of peri-implant PGCL and compare the expression of smooth muscle actin, Bcl-2 protein, GLUT-1, CD68, osteoprotegerin, receptor activator of nuclear factor kappa-B, Ki-67 and CD34 in these cases with PGCL and central giant cell lesions (CGCL). Clinical data were retrieved from the laboratory records and histological analysis was performed using HE-stained slides. Immunohistochemical reactions for the above mentioned antibodies were performed and digitally scored. Peri-implant PGCL mostly affected the posterior mandible of adult females. CD68 and Bcl-2 expressions were higher in conventional PGCL and CGCL than in peri-implant PGCL (p=0.033 for CD68 and p<.0001 for Bcl-2). Microvessel density was higher in conventional peripheral than in central and peri-implant PGCL (p=0.002). Proliferative index of the mononuclear cells showed no statistically significant differences comparing the three groups but it was higher in peri-implant PGCL. The current study demonstrated that peri-implant PGCL is more common in the posterior mandible of adult females. There were some differences in microvessel density, proliferative activity and expression of CD68 and Bcl-2 among conventional PGCL, peri-implant and CGCL. Further studies are encouraged to better understand these early findings.
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