Evaluation of the osteoclastogenic process associated with RANK / RANK-L / OPG in odontogenic myxomas

  1. Maria del Carmen Gonzalez Galvan 1
  2. Adalberto Mosqueda Taylor 2
  3. Ronell Bologna Molina 3
  4. Amaia Setién Olarra 4
  5. Xabier Marichalar Mendia 4
  6. José Manuel Aguirre Urizar 4
  1. 1 Faculty of Dentistry, National University of Asunción, Paraguay. Scholarship by Itaipú Binacional- Paraguay
  2. 2 Health Care Department, Universidad Autónoma Metropolitana Xochimilco, Ciudad de México, México
  3. 3 Faculty of Dentistry, University of the Republic (UDELAR), Uruguay
  4. 4 UFI 11/25. Department of Stomatology II. Faculty of Medicine and Nursing. University of the Basque Country (UPV/EHU), Leioa, Spain
Medicina oral, patología oral y cirugía bucal. Ed. inglesa

ISSN: 1698-6946

Year of publication: 2018

Volume: 23

Issue: 3

Pages: 9

Type: Article

DOI: 10.4317/MEDORAL.22372 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Medicina oral, patología oral y cirugía bucal. Ed. inglesa


Odontogenic myxoma (OM) is a benign intraosseous neoplasm that exhibits local aggressiveness and high recurrence rates. Osteoclastogenesis is an important phenomenon in the tumor growth of maxillary neoplasms. RANK (Receptor Activator of Nuclear Factor κappa B) is the signaling receptor of RANK-L (Receptor activator of nuclear factor kappa-Β ligand) that activates the osteoclasts. OPG (osteoprotegerin) is a decoy receptor for RANK-L that inhibits pro-osteoclastogenesis. The RANK / RANKL / OPG system participates in the regulation of osteolytic activity under normal conditions, and its alteration has been associated with greater bone destruction, and also with tumor growth. To analyze the immunohistochemical expression of OPG, RANK and RANK-L proteins in odontogenic myxomas (OMs) and their relationship with the tumor size. Eighteen OMs, 4 small (<3 cm) and 14 large (> 3cm) and 18 dental follicles (DF) that were included as control were studied by means of standard immunohistochemical procedure with RANK, RANKL and OPG antibodies. For the evaluation, 5 fields (40x) of representative areas of OM and DF were selected where the expression of each antibody was determined. Descriptive and comparative statistical analyses were performed with the obtained data. There are significant differences in the expression of RANK in OM samples as compared to DF (p = 0.022) and among the OMSs and OMLs (p = 0.032). Also a strong association is recognized in the expression of RANK-L and OPG in OM samples. Activation of the RANK / RANK-L / OPG triad seems to be involved in the mechanisms of bone balance and destruction, as well as associated with tumor growth in odontogenic myxomas.

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