The role of microRNAs in oral lichenoid disorders. Systematic review

  1. Amaia Setién Olarra 1
  2. María Luisa Gainza Cirauqui 2
  3. José Manuel Aguirre Urizar 1
  4. Xabier Marichalar Mendia 1
  1. 1 Oral Medicine and Pathology, Department of Stomatology II, UFI 11/25, University of the Basque Country (UPV/EHU), Leioa, Spain
  2. 2 Department of Dental Surgery, Faculty of Dental Surgery, University of Malta, Msida, Malta
Revista:
Medicina oral, patología oral y cirugía bucal. Ed. inglesa

ISSN: 1698-6946

Año de publicación: 2017

Volumen: 22

Número: 5

Páginas: 5

Tipo: Artículo

DOI: 10.4317/MEDORAL.21819 DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Medicina oral, patología oral y cirugía bucal. Ed. inglesa

Objetivos de desarrollo sostenible

Resumen

Certain changes in the microRNA expression are considered to be associated with chronic inflammatory processes and with the malignant transformation of oral potentially malignant disorders. The purpose of this systematic review is to update the existing data on the aberrant microRNA expression profiles identified in oral lichenoid disease (OLD). A search in PubMed-Medline and Scopus was performed on the English literature published between 2010 and August 2016 using the following keywords: oral lichenoid disease, oral lichen planus and microRNA. Originally, 25 articles were considered, of which 12 case-control articles were selected according to the inclusion/exclusion criteria. OLD seems to have altered microRNA expression profile. Certain altered microRNAs (146a, 155) may be useful as biomarkers for this disorder. More studies including larger number of cases are needed in order to study further on the biological processes and on the regulation pathways of these altered microRNAs.

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