The role of microRNAs in oral lichenoid disorders. Systematic review

  1. Amaia Setién Olarra 1
  2. María Luisa Gainza Cirauqui 2
  3. José Manuel Aguirre Urizar 1
  4. Xabier Marichalar Mendia 1
  1. 1 Oral Medicine and Pathology, Department of Stomatology II, UFI 11/25, University of the Basque Country (UPV/EHU), Leioa, Spain
  2. 2 Department of Dental Surgery, Faculty of Dental Surgery, University of Malta, Msida, Malta
Medicina oral, patología oral y cirugía bucal. Ed. inglesa

ISSN: 1698-6946

Year of publication: 2017

Volume: 22

Issue: 5

Pages: 5

Type: Article

DOI: 10.4317/MEDORAL.21819 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Medicina oral, patología oral y cirugía bucal. Ed. inglesa

Sustainable development goals


Certain changes in the microRNA expression are considered to be associated with chronic inflammatory processes and with the malignant transformation of oral potentially malignant disorders. The purpose of this systematic review is to update the existing data on the aberrant microRNA expression profiles identified in oral lichenoid disease (OLD). A search in PubMed-Medline and Scopus was performed on the English literature published between 2010 and August 2016 using the following keywords: oral lichenoid disease, oral lichen planus and microRNA. Originally, 25 articles were considered, of which 12 case-control articles were selected according to the inclusion/exclusion criteria. OLD seems to have altered microRNA expression profile. Certain altered microRNAs (146a, 155) may be useful as biomarkers for this disorder. More studies including larger number of cases are needed in order to study further on the biological processes and on the regulation pathways of these altered microRNAs.

Bibliographic References

  • Scully, C, Carrozzo, M. (2014). Oral mucosal disease: Lichen planus. Br J Oral Maxillofac Surg. 46. 15-21
  • Cortés-Ramírez, DA, Gainza-Cirauqui, ML, Echebarria-Goikouria, MA, Aguirre-Urizar, JM. (2009). Oral lichenoid disease as a premalignant condition: the controversies and the unknown. Med Oral Patol Oral Cir Bucal. 14. 118-122
  • van der Waal, I. (2009). Potentially malignant disorders of the oral and oropharyngeal mucosa, terminology, classification and present concepts of management. Oral Oncol. 45. 317
  • Gandolfo, S, Richiardi, L, Carrozzo, M, Broccoletti, R, Carbone, M, Pagano, M. (2004). Risk of oral squamous cell carcinoma in 402 patients with oral lichen planus: a follow-up study in an Italian population. Oral Oncol. 40. 77-83
  • van der Meij, EH, Mast, H, van der Waal, I. (2007). The possible premalignant character of oral lichen planus and oral lichenoid lesions: a prospective five-year follow-up study of 192 patients. Oral Oncol. 43. 742
  • Filipowicz, W, Bhattacharyya, SN, Sonenberg, N. (2008). Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?. Nat Rev Genet. 9. 102
  • Bartel, DP. (2009). MicroRNAs: target recognition and regulatory functions. Cell. 136. 215
  • Kozomara, A, Griffiths-Jones, S. (2014). miRBase: annotating high confidence microRNAs using deep sequencing data. Nucleic Acids Res. 42. 68-73
  • Kent, OA, Mendell, JT. (2006). A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenes. Oncogene. 25. 6188
  • Cervigne, NK, Reis, PP, Machado, J, Sadikovic, B, Bradley, G, Galloni, NN. (2009). Identification of a microRNA signature associated with progression of leukoplakia to oral carcinoma. Hum Mol Genet. 18. 4818
  • Wu, X, Ajani, JA, Gu, J, Chang, DW, Tan, W, Hildebrandt, MA. (2013). MicroRNA expression signatures during malignant progression from Barrett's esophagus to esophageal adenocarcinoma. Cancer Prev Res (Phila). 6. 196-205
  • De Sarkar, N, Roy, R, Mitra, JK, Ghose, S, Chakraborty, A, Paul, RR. (2014). A quest for miRNA bio-marker: a track back approach from gingivo buccal cancer to two different types of precancers. PLoS One. 9. 104839
  • Zhang, WY, Liu, W, Zhou, YM, Shen, XM, Wang, YF, Tang, GY. (2012). Altered microRNA expression profile with miR-27b down-regulation correlated with disease activity of oral lichen planus. Oral Dis. 18. 265
  • Setién-Olarra, A, Bediaga, NG, Acha-Sagredo, A, Marichalar-Mendia, X, de Pancorbo, MM, Aguirre-Urizar, JM. (2016). Genomewide miRNA profiling of oral lichenoid disorders and oral squamous cell carcinoma. Oral Dis. 22. 754
  • Chen, CZ, Li, L, Lodish, HF, Bartel, DP. (2004). MicroRNAs modulate hematopoietic lineage differentiation. Science. 303. 83
  • Nylander, E, Ebrahimi, M, Wahlin, Y. (2012). B, Boldrup L, Nylander K. Changes in miRNA expression in sera and correlation to duration of disease in patients with multifocal mucosal lichen planus. J Oral Pathol Med. 41. 86
  • Gassling, V, Hampe, J, Acil, Y, Braesen, JH, Wiltfang, J, Hasler, R. (2013). Disease-associated miRNA-mRNA networks in oral lichen planus. PLoS One. 8. 63015
  • Byun, JS, Hong, SH, Choi, JK, Jung, JK, Lee, HJ. (2015). Diagnostic profiling of salivary exosomal microRNAs in oral lichen planus patients. Oral Dis. 21. 987
  • Shi, W, Yang, J, Li, S, Shan, X, Liu, X, Hua, H. (2015). Potential involvement of miR-375 in the premalignant progression of oral squamous cell carcinoma mediated via transcription factor KLF5. Oncotarget. 24. 40172
  • Arão, TC, Guimaraes, AL, de Paula, AM, Gomes, CC, Gomez, RS. (2014). Increased miRNA-146a and miRNA-155 expressions in oral lichen planus. Arch Dermatol Res. 304. 371
  • Danielsson, K, Wahlin, YB, Gu, X, Boldrup, L, Nylander, K. (2012). Altered expression of miR-21, miR-125b, and miR-203 indicates a role for these microRNAs in oral lichen planus. J Oral Pathol Med. 41. 90
  • Dang, J, Bian, YQ, Sun, JY, Chen, F, Dong, GY, Liu, Q. (2013). MicroRNA-137 promoter methylation in oral lichen planus and oral squamous cell carcinoma. J Oral Pathol Med. 42. 315
  • Hu, JY, Zhang, J, Ma, JZ, Liang, XY, Chen, GY, Lu, R. (2015). MicroRNA-155-IFN-γ Feedback Loop in CD4+ T Cells of Erosive type Oral Lichen Planus. Sci Rep. 23. 16935
  • Shen, Z, Du, G, Zhou, Z, Liu, W, Shi, L, Xu, H. (2015). Aberrant expression of interleukin-22 and its targeting microRNAs in oral lichen planus: a preliminary study. J Oral Pathol Med. 45. 523
  • Yang, JG, Sun, YR, Chen, GY, Liang, XY, Zhang, J, Zhou, G. (2016). Different Expression of MicroRNA-146a in Peripheral Blood CD4(+) T Cells and Lesions of Oral Lichen Planus. Inflammation. 39. 860
  • Rogler, CE, Levoci, L, Ader, T, Massimi, A, Tchaikovskaya, T, Norel, R. (2009). MicroRNA-23b cluster microRNAs regulate transforming growth factor-beta/bone morphogenetic protein signaling and liver stem cell differentiation by targeting Smads. Hepatology. 50. 575
  • Akhtar, N, Rasheed, Z, Ramamurthy, S, Anbazhagan, AN, Voss, FR, Haqqi, TM. (2010). MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes. Arthritis Rheum. 62. 1361
  • Zuo, YL, Gong, DP, Li, BZ, Zhao, J, Zhou, LY, Shao, FY. (2015). The TF-miRNA Coregulation Network in Oral Lichen Planus. Biomed Res Int. 2015. 731264
  • Sonkoly, E, Wei, T, Janson, PC, Saaf, A, Lundeberg, L, Tengvall-Linder, M. (2007). MicroRNAs: novel regulators involved in the pathogenesis of psoriasis? PLoS One. 2. 610
  • Nakasa, T, Miyaki, S, Okubo, A, Hashimoto, M, Nishida, K, Ochi, M. (2008). Expression of microRNA-146 in rheumatoid arthritis synovial tissue. Arthritis Rheum. 58. 1284
  • Yamasaki, K, Nakasa, T, Miyaki, S, Ishikawa, M, Deie, M, Adachi, N. (2009). Expression of microRNA-146a in osteoarthritis cartilage. Arthritis Rheum. 60. 1035
  • Williams, AE, Perry, MM, Moschos, SA, Larner-Svensson, HM, Lindsay, MA. (2008). Role of miRNA-146a in the regulation of the innate immune response and cancer. Biochem Soc Trans. 36. 1211
  • Carrozzo, M, Thorpe, R. (2009). Oral lichen planus: a review. Minerva Stomatol. 58. 519
  • Budhu, A, Ji, J, Wang, XW. (2010). The clinical potential of microRNAs. J Hematol Oncol. 3. 37
  • Michael, A, Bajracharya, SD, Yuen, PS, Zhou, H, Star, RA, Illei, GG. (2010). Exosomes from human saliva as a source of microRNA biomarkers. Oral Dis. 16. 34
  • Lee, HJ. (2014). Additional stories of microRNAs. Exp Biol Med. 239. 1275
  • Das, K, Saikolappan, S, Dhandayuthapani, S. (2013). Differential expression of miRNAs by macrophages infected with virulent and avirulent Mycobacterium tuberculosis. Tuberculosis. 93. 47-50