Functional and structural characterization of peptides derived from hiv-1 gp41 membrane proximal and transmembrane domains. Implications for anti-hiv inhibitor and inmunogen development

  1. APELLANIZ UNZALU, BEATRIZ
unter der Leitung von:
  1. Jose Luis Nieva Escandón Doktorvater/Doktormutter

Universität der Verteidigung: Universidad del País Vasco - Euskal Herriko Unibertsitatea

Fecha de defensa: 11 von Juni von 2012

Gericht:
  1. Jesús Pérez Gil Präsident/in
  2. Francesc Xabier Contreras Gómez Sekretär/in
  3. Enrique Pérez Payá Vocal
  4. Jamie K. Scott Vocal
  5. Gorka Basañez Asua Vocal
Fachbereiche:
  1. Bioquímica y Biología Molecular

Art: Dissertation

Teseo: 116155 DIALNET

Zusammenfassung

1- Relevant in vitro assays for MPER membrane activity should include:- MPER peptide redefined to bear the hydrophobic-at-interface region plus the Nterminalresidues of the TMD.- A lipid bilayer whose composition includes concentrations of cholesterol as highas those present in the viral envelope.2- Preliminary results support that in vitro assays for MPER activity, optimizedaccording to those parameters, are useful tools for new HIV-1 inhibitor and immunogendevelopment.