The role of the cationic and helper lipids on niosomes for gene delivery applicationstransfection of retina and brain as a main goal.

  1. OJEDA HERNANDEZ, Edilberto
Dirigida por:
  1. José Luis Pedraz Muñoz Director/a
  2. Gustavo Puras Ochoa Codirector/a

Universidad de defensa: Universidad del País Vasco - Euskal Herriko Unibertsitatea

Fecha de defensa: 23 de septiembre de 2016

Tribunal:
  1. Alfonso Jesús Ladislao Domínguez-Gil Hurlé Presidente/a
  2. Laura Saenz del Burgo Martínez Secretario/a
  3. Ramón Eritja Casadellà Vocal
  4. Eduardo Ruiz Hernandez Vocal
  5. Marian Martínez de Pancorbo Gómez Vocal
Departamento:
  1. Farmacia y Ciencias de los Alimentos

Tipo: Tesis

Teseo: 442855 DIALNET lock_openADDI editor

Resumen

Currently, gene delivery has become a tangible option for the treatment of several diseases. However, there are few available options in the market, where viral vectors are the preferred option due to their high transduction efficiency. Despite the advantages that viral vectors offer, there are still many concerns about their safety. To overcome this issue, non-viral vectors have rouse interesting expectations, specifically on particles based on cationic lipids, where niosomes are a promising approach due to recent findings. Unfortunately, more research is needed bejore niosomes, as gene delivery vectors, can emulate transfection efficiencies obtained with viral vectors and be launched into the market. In the present study, we have prepared and characterized in vitro niosome formulations based on different cationic lipids for their in vivo application in retina and brain.