Osteointegración de implantes de titanio con superficies activasun estudio proteómico

  1. Francisco Romero-Gavilán 1
  2. Nuno Araújo-Gomes 1
  3. Ana María Sánchez-Pérez 1
  4. Iñaki García-Arnáez 2
  5. Mikel Azkargorta 3
  6. Ibon Iloro 3
  7. Félix Elortza 3
  8. Mariló Gurruchaga 2
  9. Isabel Goñi 2
  10. Julio Suay 1
  1. 1 Universitat Jaume I
    info

    Universitat Jaume I

    Castelló de la Plana, España

    ROR https://ror.org/02ws1xc11

  2. 2 Universidad del País Vasco/Euskal Herriko Unibertsitatea
    info

    Universidad del País Vasco/Euskal Herriko Unibertsitatea

    Lejona, España

    ROR https://ror.org/000xsnr85

  3. 3 Centro de Investigación Cooperativa en Biotecnología
    info

    Centro de Investigación Cooperativa en Biotecnología

    Zamudio, España

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Revista:
Gaceta dental: Industria y profesiones

ISSN: 1135-2949

Año de publicación: 2017

Número: 297

Páginas: 106-124

Tipo: Artículo

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Otras publicaciones en: Gaceta dental: Industria y profesiones

Resumen

Titanium is a biomaterial largely used on dental implant manufacturing. However, as a consequence of its intrinsically low bioactivity, the development of distinct superficial treatments in order to enhance its osseointegration properties is being studied. In this sense, the use of titanium implants with a higher level of roughness has been broadened, recurring to the application of sand-blasted acid-etched surface treatments. In this article, a study of two distinct titanium surface treatments has been carried out, regarding the physico-chemical properties (roughness, hydrophilicity and chemical composition) of each, as well as the pattern of adhered proteins onto each surface (proteomic study). Hence, mass spectrometry analysis allowed the detection of 218 distinct adsorbed proteins, being 37 of those related to bone regenerative processes and dental implant integration. Moreover, using differential quantification between associated proteins, comparing surfaces, it was observable a greater affinity of APOE, ANT3 and PROC proteins to the treated surface, directly linked to the bone regenerative process. On the other hand, the treated surface displays lower affinity of CO3 protein. The variations between the adsorbed protein profiles could be an explanation for distinct in vivo outcomes.

Fuente de los datos: Dialnet