Función endotelial en esclerosis múltiple y migrañaestudio transversal con comparador activo

  1. González Quintanilla, Vicente
Supervised by:
  1. Jesús Castillo Obeso Director
  2. Agustín Oterino Durán Director

Defence university: Universidad de Cantabria

Fecha de defensa: 22 December 2015

Committee:
  1. María del Carmen Fariñas Álvarez Chair
  2. Julio Pascual Gómez Secretary
  3. Alfredo Rodríguez-Antigüedad Zarranz Committee member

Type: Thesis

Teseo: 396892 DIALNET lock_openUCrea editor

Abstract

Endothelial dysfunction is an early step in the development of atherosclerosis. Autoimmune diseases, as rheumatoid arthritis (RA), have an increase in the incidence of cardiovascular disease. Several studies showed an increase prevalence of cardiovascular events in Multiple sclerosis (MS) patients, and other disorders as migraine. Our aim is to evaluate the presence of subclinical markers of endothelial dysfunction in MS and migraine patients without cardiovascular risk factors compared with healthy controls. A group of patients with RA followed at our hospital was also enrolled, as an active comparator. Biochemical and ultrasounds examinations were performed measuring the intima media thickness (IMT), flow mediated vasodilation (FMD), cerebral vasorreactivity (CVR) and others. MS patients had a significant higher IMT and lower FMD and VRC than in control group. Ultrasounds values had a highly significant correlation with inflammation biomarkers. Between migraneurs, chronic migraine patients showed higher difference. In summary we found an alteration in the endothelial function in patients with MS, and migraine, especially in chronic migraine.