Función endotelial en esclerosis múltiple y migrañaestudio transversal con comparador activo

  1. González Quintanilla, Vicente
unter der Leitung von:
  1. Jesús Castillo Obeso Doktorvater/Doktormutter
  2. Agustín Oterino Durán Doktorvater/Doktormutter

Universität der Verteidigung: Universidad de Cantabria

Fecha de defensa: 22 von Dezember von 2015

Gericht:
  1. María del Carmen Fariñas Álvarez Präsident/in
  2. Julio Pascual Gómez Sekretär/in
  3. Alfredo Rodríguez-Antigüedad Zarranz Vocal

Art: Dissertation

Teseo: 396892 DIALNET lock_openUCrea editor

Zusammenfassung

Endothelial dysfunction is an early step in the development of atherosclerosis. Autoimmune diseases, as rheumatoid arthritis (RA), have an increase in the incidence of cardiovascular disease. Several studies showed an increase prevalence of cardiovascular events in Multiple sclerosis (MS) patients, and other disorders as migraine. Our aim is to evaluate the presence of subclinical markers of endothelial dysfunction in MS and migraine patients without cardiovascular risk factors compared with healthy controls. A group of patients with RA followed at our hospital was also enrolled, as an active comparator. Biochemical and ultrasounds examinations were performed measuring the intima media thickness (IMT), flow mediated vasodilation (FMD), cerebral vasorreactivity (CVR) and others. MS patients had a significant higher IMT and lower FMD and VRC than in control group. Ultrasounds values had a highly significant correlation with inflammation biomarkers. Between migraneurs, chronic migraine patients showed higher difference. In summary we found an alteration in the endothelial function in patients with MS, and migraine, especially in chronic migraine.