Identification of proteomic biomarkers for the prediction of implant biological responses

Abstract

Giving the pressing need to develop biomaterials with better properties for implantology, it is crucial its optimal production and characterization. Right on the moment after their implantation on the patient, biomaterials comes in contact with bodily fluids forming a layer of proteins on their surface. This layer of proteins performs key roles on multiple biological processes, determining its success or failure. Considering the important function of these proteins, this doctoral thesis is centered on the proteomic characterization of serum protein adsorption on distinct materials using mass spectrometry analysis. Biomaterials with distinct properties are systematically designed to control the biological response of the host. These materials are characterized by proteomics, in vitro and in vivo. This information allows the correlation between the movements detected on protein patterns and the biological response of the material, obtaining biomakers that could predict the in vivo response of future biomaterials.