Ensayos clínicos precoces en oncología pediátrica en España: una perspectiva nacional

  1. Francisco Bautista 1
  2. Soledad Gallego 2
  3. Adela Cañete 3
  4. Jaume Mora 4
  5. Cristina Díaz de Heredia 2
  6. Ofelia Cruz 4
  7. José María Fernández 3
  8. Susana Rives 4
  9. Pablo Berlanga 3
  10. Raquel Hladun 2
  11. Antonio Juan Ribelles 3
  12. Luis Madero 1
  13. Manuel Ramírez 1
  14. Rafael Fernández Delgado 5
  15. Antonio Pérez-Martínez 6
  16. Cristina Mata 7
  17. Anna Llort 2
  18. Javier Martín Broto
  19. María Elena Cela 7
  20. Gema Ramírez 8
  21. Constantino Sábado 2
  22. Tomás Acha 9
  23. Itziar Astigarraga 10
  24. Ana Sastre 6
  25. Ascensión Muñoz 11
  26. Mercedes Guibelalde 12
  27. Lucas Moreno 1
  28. Show all authors +
  1. 1 Unidad de Investigación Clínica CNIO-HNJ, Servicio de Hematología, Oncología y Trasplante de Progenitores Hematopoyéticos, Hospital Infantil Universitario Niño Jesús, Madrid, España
  2. 2 Unidad de Oncología Pediátrica, Hospital Vall d'Hebron, Barcelona, España
  3. 3 Unidad de Oncología Pediátrica, Hospital Universitario y Politécnico La Fe, Valencia, España
  4. 4 Unidad de Oncología Pediátrica, Hospital Sant Joan de Déu, Barcelona, España
  5. 5 Unidad de Oncología Pediátrica, Hospital Clínico, Valencia, España
  6. 6 Unidad de Oncología Pediátrica, Hospital La Paz, Madrid, España
  7. 7 Unidad de Oncología Pediátrica, Hospital Gregorio Marañón, Madrid, España
  8. 8 Unidad de Oncología Pediátrica, Hospital Virgen del Rocío, Sevilla, España
  9. 9 Unidad de Oncología Pediátrica, Hospital Carlos Haya, Málaga, España
  10. 10 Unidad de Oncología Pediátrica, Hospital Universitario Cruces, Barakaldo, IIS BioCruces, Universidad del País Vasco (UPV/EHU), España
  11. 11 Unidad de Oncología Pediátrica, Hospital Miguel Servet, Zaragoza, España
  12. 12 Unidad de Oncología Pediátrica, Hospital Universitario Son Espases, Palma de Mallorca, España
Show affiliations +
Journal:
Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría ( AEP )

ISSN: 1695-4033,  1696-4608

Year of publication: 2017

Volume: 87

Issue: 3

Pages: 155-163

Type: Article

DOI: 10.1016/J.ANPEDI.2016.07.007 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría ( AEP )

Abstract

Introduction Cancer is the leading cause of death between the first year of life and adolescence, and some types of diseases are still a major challenge in terms of cure. There is, therefore, a major need for new drugs. Recent findings in cancer biology open the door to the development of targeted therapies against individual molecular changes, as well as immunotherapy. Promising results in adult anti-cancer drug development have not yet been translated into paediatric clinical practice. A report is presented on the activity in early paediatric oncology trials (phase I-II) in Spain. Material and methods All members of the Spanish Society of Paediatric Haematology Oncology (SEHOP) were contacted in order to identify early clinical trials in paediatric cancer opened between 2005 and 2015. Results A total of 30 trials had been opened in this period: 21 (70%) in solid tumours, and 9 (30%) in malignant haemopathies. A total of 212 patients have been enrolled. The majority was industry sponsored (53%). Since 2010, four centres have joined the international consortium of Innovative Therapies for Children with Cancer (ITCC), which has as its aim to develop novel therapies for paediatric tumours. A significant number of new studies have opened since 2010, improving the treatment opportunities for our children. Results of recently closed trials show the contribution of Spanish investigators, the introduction of molecularly targeted agents, and their benefits. Conclusions The activity in clinical trials has increased in the years analysed. The SEHOP is committed to develop and participate in collaborative academic trials, in order to help in the advancement and optimisation of existing therapies in paediatric cancer.

Data source: Dialnet