Trasplante de membrana amniotica en la reconstrucción de superficie ocular.

  1. Peris Martínez, Cristina
Supervised by:
  1. Manuel Díaz Llopis Director
  2. José Luis Menezo Rozalen Director

Defence university: Universitat de València

Fecha de defensa: 10 June 2005

Committee:
  1. Francisco Javier Romero Gomez Chair
  2. Antonia Fons Moreno Secretary
  3. José Belmonte Martínez Committee member
  4. Pilar Ivorra Lahuerta Committee member
  5. José Ramón Hueso Abancéns Committee member

Type: Thesis

Teseo: 103274 DIALNET lock_openTDX editor

Abstract

Current indications for amniotic membrane transplantation in ophthalmic pathology are stablishing. We have developed this thesis doctoralis in a double way: one investigative and one clinic, to evaluate the usefullness of amniotic membrane transplantation for the reconstruction of the ocular surace. In the first way, we have applied an experimental model of coneal alkali injury wth limbus compromise in 40 rabbit eyes. Spontaneous evolution of lesions in control group without amniotic membrane is to corneal opacity, neovascularization and corneal conjunctivalization. We have demostrated amniotic membrane transplantation in ocular surface regenaration in the experimental model we have proposed, improving both corneal opacity and neovascularization in rabbit eyes with amniotic membrane transplantation comparing with control group. Clinical study was developed in 64 eyes of 63 patients with various ocular surface pathologies. Among patientes included in this study that we have operated with amniotic membrane, we conclude we have obtained best results especially in two pathologies: corneal decompensation (bullous keratopathy) and corneal microperforations. However, in other ocular surface diseases with more conjunctival implication, we have found that conjunctival implants, are more effective than amniotic membrane transplantation.