New strategies for cardiac repair using polymer-based drug delivery systems loaded with growth factors

  1. Pascual Gil de Gómez, Simón
Supervised by:
  1. María José Blanco Prieto Director
  2. Felipe Prósper Cardoso Co-director

Defence university: Universidad de Navarra

Fecha de defensa: 25 June 2018

Committee:
  1. José Antonio Páramo Fernández Chair
  2. Josune Orbe Secretary
  3. Ana Colette Pereira de Castro Osorio Mauricio Committee member
  4. Gorka Orive Arroyo Committee member
  5. Mariana Landín Pérez Committee member

Type: Thesis

Teseo: 146906 DIALNET lock_openDadun editor

Abstract

Myocardial infarction (MI) is the main cardiovascular disease, causing more than 7 million deaths per year 1. In spite of its clinical relevance 2,3, this pathology is from been controlled and risk factors associated to it are considerably augmenting in modern society, as pointed out by the World Health Organization, which has estimated that the number of MI events will dramatically increase by 2030 1. MI is usually started by the occlusion of a coronary artery, that causes an ischemic condition in the cardiac tissue. This lack of oxygen supply induces a massive cell death of cardiac cells and a negative tissue remodeling takes place. Consequently, functional limitations and eventually death may occur.