Water encapsulation by nanomicelles

  1. León, I. 3
  2. Millán, J. 2
  3. Cocinero, E.J. 3
  4. Lesarri, A. 1
  5. Fernández, J.A. 3
  1. 1 Universidad de Valladolid
    info
    Universidad de Valladolid

    Valladolid, España

    ROR https://ror.org/01fvbaw18

    Geographic location of the organization Universidad de Valladolid
  2. 2 Universidad de La Rioja
    info
    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

    Geographic location of the organization Universidad de La Rioja
  3. 3 Universidad del País Vasco/Euskal Herriko Unibertsitatea
    info
    Universidad del País Vasco/Euskal Herriko Unibertsitatea

    Lejona, España

    ROR https://ror.org/000xsnr85

    Geographic location of the organization Universidad del País Vasco/Euskal Herriko Unibertsitatea
  4. 4 sdfsdfsdf
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Journal:
Angewandte Chemie International

ISSN: 1433-7851

Year of publication: 2014

Volume: 53

Issue: 46

Pages: 12480-12483

Type: Article

DOI: 10.1002/ANIE.201405652 SCOPUS: 2-s2.0-84915763003 WoS: WOS:000344649900020 GOOGLE SCHOLAR

More publications in: Angewandte Chemie International

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Abstract

Reported is the hydration of nanomicelles in the gasphase using spectroscopic methods and quantum chemical calculations. A fine-tuning of the experimental conditions allowed formation of a propofol trimer and tetramer with a water molecule and to determine the structure of the aggregates. Their electronic and IR spectra were obtained using mass-resolved laser spectroscopy, together with the number of conformational isomers for each stoichiometry. Interpretation of the spectra in the light of high-level calculations allowed determination of the cluster,s structure and demonstration that the trimer of propofol with a water molecule forms cyclic hydrogen-bond networks but, on the other hand, the tetramer is big enough to encapsulate the water molecule inside its hydrophilic core. Furthermore, these hydrated nanomicelles present an unusually high binding energy, thus reflecting their high stability and their capability to trap water inside.