Pigmentación humanadetección de selección positiva en loci candidatos y análisis de expresión genética en líneas celulares melanocíticas

  1. S. Alonso Alegre 1
  2. N. Izagirre Arribalzaga 1
  3. I. García Jiménez 1
  4. I. Smith Subyaga 1
  5. C. De la Rúa Vaca 1
  1. 1 Universidad del País Vasco/Euskal Herriko Unibertsitatea
    info

    Universidad del País Vasco/Euskal Herriko Unibertsitatea

    Lejona, España

    ROR https://ror.org/000xsnr85

Buch:
Diversidad biológica y salud humana
  1. Martínez Almagro, Andrés (ed. lit.)
  2. Armada Ros, Eduardo (col.)

Verlag: Universidad Católica San Antonio de Murcia

ISBN: 84-96353-56-7

Datum der Publikation: 2006

Seiten: 25-29

Kongress: Sociedad Española de Antropología Física. Congreso Internacional (16. 2006. Murcia)

Art: Konferenz-Beitrag

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Zusammenfassung

A pale skin and an intense solar exposure are risk factors for skin cancer. however, from an evolutionary point of view, it is less clear which is the factor that drives or has driven the evolution of the pigmentation of the human skin. thus, several hypotheses coexist, like photoprotection against skin cancer, photoprotection of circulating photolabile compounds, vitamin D síntesis, sexual selection, among others, none of them prooved. In this work we aim at identifying those loci of relevance in the pigmentary phenotype by means of two approaches: a) the identification of a signature of adaptive selection in the diversity and divergence profiles of a series of candidate loci and b) the analisis by microarrays of the expression profiles of melanocytic cell lines of different constitutive pigmentation, both irradiated and not irradiated with UV ligth (A*B).

Fuente de los datos: Dialnet