Changes in salivary composition of chemically dependent subjects

  1. Luciana Lyra 1
  2. William Bellani 1
  3. Carolina E. 1
  4. João A. Brancher 2
  5. Antonio Adilson S. De Lima 1
  6. José Miguel Amenábar 1
  1. 1 Universidade Federal do Paraná
    info

    Universidade Federal do Paraná

    Curitiba, Brasil

    ROR https://ror.org/05syd6y78

  2. 2 Pontifícia Universidade Católica do Paraná
    info

    Pontifícia Universidade Católica do Paraná

    Curitiba, Brasil

    ROR https://ror.org/02x1vjk79

Revue:
Odontología Vital

ISSN: 2215-5740 1659-0775

Année de publication: 2020

Volumen: 1

Número: 32

Pages: 63-70

Type: Article

DOI: 10.59334/ROV.V1I32.381 DIALNET GOOGLE SCHOLAR lock_openAccès ouvert editor

D'autres publications dans: Odontología Vital

Objectifs de Développement Durable

Résumé

Chemically dependent subjects may present relevant changes in the volume and composition of salivary fluid because the secretion of the salivary glands is controlled by the parasympathetic and sympathetic system. The aim of this study was to compare the salivary concentration of total proteins, amylase, urea, calcium, phosphate and flow rate between chemically dependent and non-chemically dependent subjects. Saliva flow rate, calcium, phosphate, total protein, amylase and urea concentrations were measure in both groups: chemical dependent group (n=27) and control group (n=27). Saliva samples, from the chemically dependents, were taken one day before the beginning of the detoxification treatment. Statistical analysis was undertaken using t-test. The salivary flow and the urea concentration did not present statistically significant difference between the groups. However, total proteins, amylase, calcium and phosphate concentrations were statistically higher on the chemical dependents group. Saliva composition seems to be modified by the chronic use of alcohol and illicit drugs.

Références bibliographiques

  • Antoniazzi, R. P.,Lago, F. B.,Jardim, L. C.,Sagrillo, M. R.,Ferrazzo, K. L.,Feldens, C. A.. (2018). Impact of crack cocaine use on the occurrence of oral lesions and micronuclei.. Int J Oral Maxillofac Surg. 47. 888
  • Aps, J. K.,Martens, L. C.. (2005). Review: The physiology of saliva and transfer of drugs into saliva.. Forensic Sci Int. 150. 119
  • Banderas-Tarabay, J. A.,González-Begné, M.,Sánchez-Garduño, M.,Millán-Cortéz, E.,López-Rodríguez, A.,Vilchis-Velázquez, A.. (1997). The flow and concentration of proteins in human whole saliva. Salud Publica Mex. 39. 433
  • Beal, A. M.. (1991). Effect of phosphate-regulating hormones on plasma composition, cardiovascular function, and parotid salivary phosphate secretion in red kangaroos (Macropus rufus).. Gen Comp Endocrinol. 81. 64-71
  • Carpenter, G. H.. (2013). The secretion, components, and properties of saliva. Annu Rev Food Sci Technol,. 4. 267
  • Castle, A. M.,Castle, J. D.. (1998). Enhanced glycosylation and sulfation of secretory proteoglycans is coupled to the expression of a basic secretory protein.. Mol Biol Cell. 9. 575
  • Cho, C. M.,Hirsch, R.,Johnstone, S.. (2005). General and oral health implications of cannabis use.. Aust Dent J. 50. 70
  • da Fonseca, M. A.. (2009). Substance use disorder in adolescence: a review for the pediatric dentist.. J Dent Child. 76. 209
  • Dackis, C. A.,O’Brien, C. P.. (2001). Cocaine dependence: a disease of the brain’s reward centers.. J Subst Abuse Treat. 21. 111
  • Dawes, C.. (1984). Stimulus effects on protein and electrolyte concentrations in parotid saliva.. J Physiol. 346. 579
  • Enberg, N.,Alho, H.,Loimaranta, V.,Lenander-Lumikari, M.. (2001). Saliva flow rate, amylase activity, and pro- tein and electrolyte concentrations in saliva after acute alcohol consumption.. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 92. 292
  • Gossop, M.,Manning, V.,Ridge, G.. (2006). Concurrent use and order of use of cocaine and alcohol: behavioural differences between users of crack cocaine and cocaine powder.. Addiction. 101. 1292
  • Kalivas, P. W.,Volkow, N. D.. (2005). The neural basis of addiction: a pathology of motivation and choice.. Am J Psychiatry. 162. 1403
  • Koob, G. F.. (1992). Drugs of abuse: anatomy, pharmacology and function of reward pathways.. Trends Pharmacol Sci. 13. 177
  • Macpherson, L. M.,Dawes, C.. (1991). Urea concentration in minor mucous gland secretions and the effect of salivary film velocity on urea metabolism by Streptococcus vestibularis in an artificial plaque.. J Periodontal Res. 26. 395-401
  • Magura, S.,Rosenblum, A.. (2000). Modulating effect of alcohol use on cocaine use.. Addict Behav. 25. 117
  • Newlin, D. B.. (1995). Effect of cocaine on vagal tone: a common factors approach.. Drug Alcohol Depend. 37. 211
  • Olière, S.,Joliette-Riopel, A.,Potvin, S.,Jutras-Aswad, D.. (2013). Modulation of the endocannabinoid system: vulnerability factor and new treatment target for stimulant addiction.. Front Psychiatry. 4. 109
  • Pateria, P.,de Boer, B.,MacQuillan, G.. (2013). Liver abnormalities in drug and substance abusers.. Best Pract Res Clin Gastroenterol. 27. 577
  • Proctor, G. B.. (2016). The physiology of salivary secretion. Periodontol 2000. 70. 11
  • Proctor, G. B.,Carpenter, G. H.. (2007). Regulation of salivary gland function by autonomic nerves.. Auton Neu- rosci. 133. 3-18
  • Proctor, G. B.,Carpenter, G. H.. (2014). Salivary secretion: mechanism and neural regulation.. Monogr Oral Sci. 24. 14-29
  • Ralevic, V.. (2003). Cannabinoid modulation of peripheral autonomic and sensory neurotransmission.. Eur J Phar- macol. 472. 1-21
  • Rawal, S. Y.,Tatakis, D. N.,Tipton, D. A.. (2012). Periodontal and oral manifestations of marijuana use.. J Tenn Dent Assoc. 92. 26-31
  • Reddy, S.,Kaul, S.,Agrawal, C.,Prasad, M. G.,Agnihotri, J.,Bhowmik, N.,. . . Kambali, S.. (2012). Periodontal Status amongst Substance Abusers in Indian Population. ISRN Dent.
  • Riezzo, I.,Fiore, C.,De Carlo, D.,Pascale, N.,Neri, M.,Turillazzi, E.,Fineschi, V.. (2012). Side effects of cocaine abuse: multiorgan toxicity and pathological consequences.. Curr Med Chem. 19. 5624
  • Ron, D.,Barak, S.. (2016). Molecular mechanisms underlying alcohol-drinking behaviours.. Nat Rev Neurosci. 17. 576
  • Singh, A.,Saluja, S.,Kumar, A.,Agrawal, S.,Thind, M.,Nanda, S.,Shirani, J.. (2017). Cardiovascular Complications of Marijuana and Related Substances: A Review. Cardiol Ther..
  • Sordi, M. B.,Massochin, R. C.,Camargo, A. R.,Lemos, T.,Munhoz, E. A.. (2017). Oral health assessment for users of marijuana and cocaine/crack substances.. Braz Oral Res. 31-102
  • Turner, R. J.,Sugiya, H.. (2002). Understanding salivary fluid and protein secretion. Oral Dis. 8. 3-11
  • Waszkiewicz, N.,Galinska-Skok, B.,Zalewska, A.,Szajda, S. D.,Zwierz, K.,Wiedłocha, M.,Szulc, A.. (2017). Sali- vary immune proteins monitoring can help detection of binge and chronic alcohol drinkers: Preliminary findings. Drug Alcohol Depend. 183. 13
  • Waszkiewicz, N.,Zalewska-Szajda, B.,Zalewska, A.,Waszkiewicz, M.,Szajda, S. D.,Repka, B.,. . . Zwierz, K.. (2012). Decrease in salivary lactoferrin output in chronically intoxicated alcohol-dependent patients. Folia Histochem Cytobiol. 50. 248
  • Waszkiewicz, N.,Zalewska-Szajda, B.,Zalewska, A.,Waszkiewicz, M.,Szajda, S. D.,Repka, B.,. . . Zwierz, K.. (2012). Salivary lysozyme in smoking alcohol dependent persons. Folia Histochem Cytobiol. 50. 609
  • Waszkiewicz, N.,Zalewska, A.,Szajda, S. D.,Szulc, A.,Kepka, A.,Minarowska, A.,. . . Zwierz, K.. (2012). The effect of chronic alcohol intoxication and smoking on the activity of oral peroxidase. Folia Histochem Cytobiol. 50. 450
  • Waszkiewicz, N.,Zalewska, A.,Szajda, S. D.,Waszkiewicz, M.,Szulc, A.,Kepka, A.,. . . Zwierz, K.. (2012). The effect of chronic alcohol intoxication and smoking on the output of salivary immunoglobulin A. Folia Histochem Cytobiol. 50. 605
  • Woyceichoski, I. E.,Costa, C. H.,de Araújo, C. M.,Brancher, J. A.,Resende, L. G.,Vieira, I.,de Lima, A. A.. (2013). Salivary buffer capacity, pH, and stimulated flow rate of crack cocaine users.. J Investig Clin Dent. 4. 160