Efecto del Δ9-tetrahidrocannabinol sobre la oligodendrogénesis durante la mielinización y la remilinización del sistema nervioso central

  1. HUERGA GÓMEZ, ALBA
unter der Leitung von:
  1. Tania Aguado Sanchez Doktorvater/Doktormutter
  2. Javier Palazuelos Diego Doktorvater/Doktormutter

Universität der Verteidigung: Universidad Complutense de Madrid

Fecha de defensa: 01 von Juli von 2022

Gericht:
  1. Javier Fernández Ruiz Präsident/in
  2. Eva M. Marco López Sekretär/in
  3. Beatriz Cubelos Vocal
  4. Susana Mato Santos Vocal
  5. Daniel García Ovejero Vocal

Art: Dissertation

Zusammenfassung

Oligodendrogenesis is an essential process for the formation and maintenance of axonal myelin and, consequently, for correct nerve transmission in the central nervoussystem (CNS). Multiple sclerosis (MS) is a demyelinating disease of the CNS characterizedby oligodendrocytes (OL) cell death, demyelination and axonal damage, presenting a progressive, recurrent and neurodegenerative character. Remyelination is the process by which myelin of demyelinated axons is restored spontaneously, recovering the saltatory transmission of the nerve impulse. In MS there is a deficit in the remyelination process, which is believed to be due to an insufficiency in the differentiation of oligodendrocyte progenitor cells (OPC) and, therefore, in the regeneration of myelinating OL. Therefore, the search for molecules that favor oligodendrogenesis during CNS myelination and, more importantly, in situations of demyelination, is one of the current challenges of research for the treatment of demyelinated disorders that currently have no cure...