Antiradical and antiulcer effect of Sonneratia apetala Buch-Ham leaves against alcohol induced gastric mucosal injury

  1. Sur, Dr.Tapas Kumar Sur 1
  2. Hazra, Avijit
  3. Bhattacharyya, Dipankar
  4. Hazra, Alok Kumar
  1. 1 RESEARCH SCIENTIST (SENIOR), MRU, RG KAR MEDICAL COLLEGE & HOSPITAL, KOLKATA, INDIA
Revue:
Ars pharmaceutica

ISSN: 2340-9894,  0004-2927

Année de publication: 2021

Volumen: 62

Número: 4

Pages: 348-357

Type: Article

DOI: 10.30827/ARS.V62I3.20759 DIALNET GOOGLE SCHOLAR lock_openAccès ouvert editor

D'autres publications dans: Ars pharmaceutica

Objetivos de desarrollo sostenible

Résumé

Introducción: Sonneratia apetala Buch-Ham es un verdadero habitante de los manglares en Sunderban indio y se utiliza en la medicina popular para los trastornos digestivos. Método: El extracto hidrometanólico (20:80) de hojas de Sonneratia apetala (SA) se estandarizó químicamente por HPTLC y se evaluó por sus propiedades antirradicales y gastroprotectoras. Se determinaron los fenólicos y flavonoides presentes en SA y se evaluaron las actividades antirradicales mediante métodos in vitro como, DPPH (1,1-difenil-2-picrilhidrazilo), óxidos nítricos, superóxidos, hidroxilo y ABTS (2,2 / -azino-bis- Ácido 3-etilbenztiazolin-6-sulfónico). Además, se evaluó la eficacia gastroprotectora de SA en la ulceración oxidativa inducida por alcohol (50% v / v, 5 ml / kg) en ratas. Resultados: El SA químicamente estandarizado mostró presencia de compuestos polifenólicos. También mostró fuertes propiedades antirradicales. Las administraciones orales de SA (125 mg / kg y 250 mg / kg) protegieron significativamente la membrana mucosa gástrica del daño ulcerativo causado por el alcohol, similar al omeprazol (20 mg / kg) en ratas. Además, el tratamiento con SA redujo significativamente la elevación de los peróxidos de lípidos; mientras que aumentó la concentración de glutatión y catalasa en la mucosa gástrica con respecto a las ratas de control no tratadas inducidas por etanol. Conclusiones: Los resultados obtenidos de este estudio sugieren que la hoja de Sonneratia apetala tiene propiedades antioxidantes y tiene capacidad para proteger la lesión de la mucosa gástrica causada por la ingestión de alcohol.

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