Cyclobutane-containing peptides and ureassynthesis, folding, self-assembling and some biological properties
- Gorrea Morral, Esther
- Vicenç Branchadell Gallo Doktorvater/Doktormutter
- Rosa María Ortuño Mingarro Doktorvater/Doktormutter
Universität der Verteidigung: Universitat Autònoma de Barcelona
Fecha de defensa: 07 von Februar von 2012
- Josep Maria Lluch López Präsident/in
- Jesús Jiménez Barbero Sekretär/in
- Norbert Sewald Vocal
Art: Dissertation
Zusammenfassung
Peptides and relative compounds, have been widely used and studied during the past decades. In the present thesis, an enantioselective synthesis and structural study of a variety of cyclobutane-containing beta-peptides and ureas is exposed. By means of experimental and theoretical techniques, their adoption of different folding structures due to the presence of self-assembling properties is described. These properties, in some cases, allowed the preparation of stable gels in organic solvents, which obtaintion was fully studied. In addition, the use of solid-phase peptide synthesis strategy was assaied in order to prepare hybrid cyclobutane-proline hexapeptides. Those, were studied as possible cell-penetrating agents.