2-Interleukina (IL-2) eta IL-15 seinalizazio bidezidorrak T linfozitoetanantzekoak baina aldiberean ezberdinak
- Nerea Osinalde
- Miren Josu Omaetxebarria
- Virginia-Sánchez Quiles
- Vyacheslav Akimov
- Blagoy Blagoev
- Irina Kratchmarova
ISSN: 0214-9001
Année de publication: 2016
Titre de la publication: 2013-2014 Euskal tesien 10 pasarte
Número: 1
Pages: 69-76
Type: Article
D'autres publications dans: Ekaia: Euskal Herriko Unibertsitateko zientzi eta teknologi aldizkaria
Résumé
L-2 and IL-15 are key cytokines regulating the immune system i n part by promoting T-cell proliferation. Both cytokines signal through the same receptor subunits (IL-2Rβ and IL-2Rγ) and not surprisingly they exert some overlapping functions. However they also have specific and even sometimes opposing roles raising the paradigm of how they mediate distinct immune reponses by using the same receptors. Although several options have been suggested, it remains controversial the molecular mechanism underlying the functional dichotomy of IL-2 and IL-15. Aiming to find the key to answering such enigma, we assessed and compared by mass spectrometry the signaling networks activated by both cytokines. Our study revealed that the transduction pathways initiated by IL-2 and IL-15 are highly similar but not identical since we detected faint differences that may account for the functional discrepancy observed between both cytokines.