Polycationic multivalency protein recognition and cell uptake via oligoguanidinium scaffolds
- Martos Riaño, Vera
- Javier Mendoza Sans Doktorvater/Doktormutter
Universität der Verteidigung: Universidad Autónoma de Madrid
Fecha de defensa: 24 von März von 2009
- Cecilio Giménez Martín Präsident/in
- Ugo Bastolla Sekretär/in
- Fernando Albericio Palomera Vocal
- Jesús Jiménez Barbero Vocal
- Ernest Giralt Lledó Vocal
Art: Dissertation
Zusammenfassung
Reversible interactions, based on recognition between biological macromolecules are essential for the regulation of biochemical processes: Inside the cells, proteins rarely act alone, but interact instead with each other, assembled in complexes either homo-oligomeric or formed by several different components (1). Outside the cell, processes like cell recognition, endocytosis or drug internalization are mediated by surface recognition on the cell membrane. Therefore studying the principles of biomolecular surface interactions allow for both prediction and mimicry of molecular recognition and represent an important class of targets for human therapeutics.