Sistema kannabinoidearen funtzioa ugaztunen obarioen fisiologian eta obozitoen heltze-prozesuan

Résumé

Oocyte¿s maturation is a very important process in fertility. The oocyte meiotic maturation is a complex process whereby immature oocytes acquire the characteristics required for successful fertilization and embryogenesis. For that, immature oocytes arrested at the diplotene of prophase I (GV) must resume meiosis until the metaphase II of meiosis (MII). However, although all the mechanisms that leads for the reactivation of meiosis are not still known, there are known certain molecules that are able to modulate this process.That¿s way we were interested in the role that cannabinoids could have as IVM promoters because cannabinoid¿s molecular pathway is similar to the one by whuc oocyte¿s meiosis resumption is activated. That¿s why, the aim of this Doctoral Thesis was to study the function of the cannabinoid system in teh process of folliculogenesis, ovogenesis and oocyte maturation. Teh results obtained in the following PhD thesis confirm its participation. Beyond that we have seen that in fact, the phytocannabinoid (THC) in the IVM process, due to its possible use in clinic is most feasible and reliable than any synthetic cannabinoid. The most important goal of IVM method is that could be the only hope or an alternative for a not insignificant numer of patients. // Oocyte¿s maturation is a very important process in fertility. The oocyte meiotic maturation is a complex process whereby immature oocytes acquire the characteristics required for successful fertilization and embryogenesis. For that, immature oocytes arrested at the diplotene of prophase I (GV) must resume meiosis until the metaphase II of meiosis (MII). However, although all the mechanisms that leads for the reactivation of meiosis are not still known, there are known certain molecules that are able to modulate this process.That¿s way we were interested in the role that cannabinoids could have as IVM promoters because cannabinoid¿s molecular pathway is similar to the one by whuc oocyte¿s meiosis resumption is activated. That¿s why, the aim of this Doctoral Thesis was to study the function of the cannabinoid system in teh process of folliculogenesis, ovogenesis and oocyte maturation. Teh results obtained in the following PhD thesis confirm its participation. Beyond that we have seen that in fact, the phytocannabinoid (THC) in the IVM process, due to its possible use in clinic is most feasible and reliable than any synthetic cannabinoid. The most important goal of IVM method is that could be the only hope or an alternative for a not insignificant numer of patients.