A simple NMR analysis of the protonation equilibrium that accompanies aminoglycoside recognition. Dramatic alterations in neomycin-B protonation state upon binding to a 23-mer RNA aptamer

  1. Freire, F. 1
  2. Cuesta, I. 1
  3. Corzana, F. 2
  4. Revuelta, J. 1
  5. González, C. 3
  6. Hricovini, M. 4
  7. Bastida, A. 1
  8. Jiménez-Barbero, J. 5
  9. Asensio, J.L. 1
  1. 1 Instituto de Química Orgánica General
    info

    Instituto de Química Orgánica General

    Madrid, España

    ROR https://ror.org/05e0q7s59

  2. 2 Universidad de La Rioja
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    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

  3. 3 Instituto de Química Física Rocasolano
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    Instituto de Química Física Rocasolano

    Madrid, España

    ROR https://ror.org/03xk60j79

  4. 4 Slovak Academy of Science, Institute of Chemistry, Bratislava 84538, Slovakia
  5. 5 Centro de Investigaciones Biológicas
    info

    Centro de Investigaciones Biológicas

    Madrid, España

    ROR https://ror.org/04advdf21

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Revue:
Chemical Communications

ISSN: 1359-7345

Année de publication: 2007

Volumen: 2

Número: 2

Pages: 174-176

Type: Article

DOI: 10.1039/B611597G PMID: 17180237 SCOPUS: 2-s2.0-33845784390 WoS: WOS:000242979300020 GOOGLE SCHOLAR

D'autres publications dans: Chemical Communications

Résumé

A complete characterisation of the protonation equilibrium that accompanies the molecular recognition of neomycin-B by a specific RNA receptor has been achieved by employing simple NMR measurements. © The Royal Society of Chemistry.